Isopropyl chloroformate → HCID 58945837, compound

Participants

Reaction Steps

4-[1-(2-Fluorophenyl)-1H-[1,2,3]-triazol-4-yl]-1,2,3,6-tetrahydropyridine hydrochloride (22.7 mg) prepared in the above 1) was dissolved in 0.5 ml of pyridine and 0.06 ml of isopropyl chloroformate was added thereto followed by stirring for 1 hour. A saturated aqueous solution of ammonium chloride was added to the reaction solution and the product was extracted with ethyl acetate, dried over sodium sulfate and the solvent was evaporated in vacuo. The resulting residue was separated and purified by a thin-layer chromatography (ethyl acetate/hexane=1/1) to give 4.9 mg of the title compound as a white solid.

Provenance & Evidence