2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester → Oxane-4-carboxamide

To methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) was added concentrated ammonia water (50 mL), and the reaction mixture was stirred at room temperature for 43.5 hours. Thereafter, the reaction mixture was cooled in an ice water bath, and the precipitate was filtrated. Then, the precipitate was dried at 40° C. under reduced pressure, to obtain 33.4 g of a title compound (yield: 74.6%).

1. temperatureThereafter, the reaction mixture was cooled in an ice water bath
2. filtrationthe precipitate was filtrated
3. customThen, the precipitate was dried at 40° C. under reduced pressure

ORD record

ord-52cee181ad674e5d8c576a9baf01d46a

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07858809B2