Hydrochloric Acid → HCID 86632272, compound

Participants

Reaction Steps

5-tert-Butyl-7-(4-tert-butylphenyl)-2-methyl-1-indanone (10.37 g, 31mmol) in Et2O (150 ml) was added dropwise at 0° C. to LiAlH4 (0.6 g, 16 mmol) in Et2O (100 ml). After 1 h of stirring, 5% HCl (50 ml) was added, the organic phase was separated, the water layer was extracted in Et2O (2×50 ml). The combined organic phase was washed with aq. Na2CO3, dried over MgSO4 and evaporated. The residue was dissolved in benzene (500 ml), p-TSA (1 g) was added, the resulting mixture was refluxed for 10 min, cooled, washed with water, dried over MgSO4, evaporated and dried in vacuo. The yield was 9.9 g (near quantitative); yellow viscous oil.

Provenance & Evidence