Ethyl [(1'-benzyl-[1,4']bipiperidinyl-4-yl)-tert-butoxycarbonyl-amino]-acetate → Ethyl([1,4']bipiperidinyl-4-yl-tert-butoxycarbonyl-amino)-acetate

HRID 2267223Notes

Reaction equation

HRID 2267223 reaction equation
[CH2:1]([O:3][C:4](=[O:33])[CH2:5][N:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:25][CH2:24][N:23](CC3C=CC=CC=3)[CH2:22][CH2:21]2)[CH2:16][CH2:15]1)[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH3:2].[H][H]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:33])[CH2:5][N:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)[CH2:16][CH2:15]1)[C:7]([O:9][C:10]([CH3:13])([CH3:11])[CH3:12])=[O:8])[CH3:2]

Participants

5

Reactant 2

HCID 86650915Ethyl [(1'-benzyl-[1,4']bipiperidinyl-4-yl)-tert-butoxycarbonyl-amino]-acetateHCID 178418361HCID 178418361, compound

Product 1

HCID 57807378Ethyl([1,4']bipiperidinyl-4-yl-tert-butoxycarbonyl-amino)-acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 1.30 g (2.83 mmol) ethyl[(1′-benzyl-[1,4′]bipiperidinyl-4-yl)-tert-butoxycarbonyl-amino]-acetate and 0.16 g 10% Pd/C in 25 mL EtOH was hydrogenated for 5 h at 50° C. and 50 psi hydrogen pressure. The catalyst was removed by suction filtering and the filtrate was evaporated to dryness. The product was obtained as a colourless oil, which was reacted further without purification.

Workup

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. customthe filtrate was evaporated to dryness
  4. customThe product was obtained as a colourless oil, which
  5. customwas reacted further without purification

Sources & evidence

ORD record
ord-0750d7dc325d4d209869c787cd41fb75
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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