Ethanol → HCID 66942083, compound

HRID 2267228Notes

Reaction equation

HRID 2267228 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](C(OCCCC2C=CC=CC=2)=O)[C@H:4]([C:20]([O-:22])=[O:21])[CH2:3]1.[H][H].[CH3:25][CH2:26]O>[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][C@H:4]([C:20]([O:22][CH2:25][CH3:26])=[O:21])[CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 86650917HCID 86650917, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66942083HCID 66942083, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A suspension of 2.04 (6.66 mmol) 1-benzyl-2-ethyl(S)-4-methyl -piperazine-1,2-dicarboxylate and 200 mg 10% Pd/C in 100 mL EtOH was hydrogenated at 50° C. and 3447 hPa hydrogen pressure for 6 h. The catalyst was filtered off, the filtrate was evaporated to dryness i. vac. and the residue was further reacted without any purification.

Workup

  1. customwas hydrogenated at 50° C.
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated to dryness i
  4. customand the residue was further reacted without any purification

Sources & evidence

ORD record
ord-c3035ff621ce46c5810761c15cf6e93e
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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