Triethylamine → HCID 131727597, compound

Participants

Reaction Steps

48 mg (0.15 mmol) TBTU, 21 μL (0.15 mmol) triethylamine and 15 mg (0.15 mmol) 2-hydroxy-N,N-dimethyl-acetamide were added to a solution of 100 mg (0.13 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-(1′-carboxymethyl-4,4′-bipiperidinyl-1-yl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 1 mL DMF and the reaction mixture was stirred overnight at RT. The reaction solution was filtered through a syringe filter and the crude product was purified by HPLC. The fractions containing the product were combined and evaporated down i. vac.

Provenance & Evidence