2-Morpholinoethanol → HCID 16071536, compound

HRID 2267247Notes

Reaction equation

HRID 2267247 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:40][C:41]3[CH:46]=[C:45]([C:47]([F:50])([F:49])[F:48])[C:44]([NH2:51])=[C:43]([Cl:52])[CH:42]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:32][CH2:31][N:30]([C:33](=[O:39])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:53]=[CH:54][CH:55]=[CH:56][C:4]=2[NH:3]1.[N:57]1([CH2:63][CH2:64]O)[CH2:62][CH2:61][O:60][CH2:59][CH2:58]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:40][C:41]3[CH:46]=[C:45]([C:47]([F:48])([F:50])[F:49])[C:44]([NH2:51])=[C:43]([Cl:52])[CH:42]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:28][CH2:29][N:30]([C:33](=[O:39])[CH2:34][CH2:35][C:36]([O:38][CH2:64][CH2:63][N:57]5[CH2:62][CH2:61][O:60][CH2:59][CH2:58]5)=[O:37])[CH2:31][CH2:32]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:53]=[CH:54][CH:55]=[CH:56][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 611632-MorpholinoethanolHCID 16045880HCID 16045880, compound

Product 1

HCID 16071536HCID 16071536, compound

Procedure

Prepared analogously to Example 9.2 from 100 mg (0.12 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[1′-(3-carboxy-propionyl)-4,4′-bipiperidinyl-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 17 μL (0.14 mmol) 2-morpholin-4-yl-ethanol.

Sources & evidence

ORD record
ord-068176e8375f4f8691d4b7def7997095
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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