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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 226727Generated: October 25, 2026

M-Phenylenediamine → N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine

https://huagongshe.com/reaction/226727

Reaction equation

Participants

RoleNameHCIDCharge
ReactantM-PhenylenediamineHCID 7935—
Reactant2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060451—
ProductN2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamineHCID 22060474—

Reaction Steps

In like manner to the preparation of N4-(3-aminophenyl)-N2-[2-(methoxycarbonyl)-benzofurane-5-yl]-5-fluoro-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 1,3-diaminobenzene were reacted to give N2-(3-aminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 11.89 min.; purity: 97.6%; MS (m/e): 312.05 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557210B2
Source datasetuspto-grants-2009_07
ORD IDord-087dea1b716f488c97cee989669d81c5
Source noteuspto-grants-2009_07