Triethylamine → HCID 57848474, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Reactant	HCID 57807329	HCID 57807329	—
Reactant	(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate	HCID 58202073	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 57848474	HCID 57848474	—

Reaction Steps

A mixture of 1.00 g (1.80 mmol) (R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (Example 1f), 546 mg (1.80 mmol) benzyl 4-piperazin-1-yl -piperidine-1-carboxylate (Example A17b), 643 mg (2.00 mmol) TBTU and 0.35 mL (2.50 mmol) triethylamine in 10 mL DMF was stirred overnight at RT. This was combined with 150 mL of 15% K2CO3 solution, the precipitate was removed by suction filtering, washed with 30 mL water and the crude product was dried at 40° C. in the drying cupboard.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07858622B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-47470b95ad8f4eaba43eff61ae2df936
Source note	uspto-grants-2010_12