HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(2-Amino-ethyl)-5,5-dimethyl-imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester | HCID 57428814 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Amino-ethyl)-5,5-dimethyl-imidazolidin-2-one | HCID 57428813 | 93% |
Reaction Steps
[2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (450 mg, 1.75 mmol) was dissolved in DCM (5 mL) and TFA (1 mL) was added. The mixture was allowed to stand for 16 h, concentrated, and purified by SCX ion exchange chromatography to give the product as a yellow oil (256 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-ce8254b17d3e4b90bdd9f6e65b5305cd |
| Source note | uspto-grants-2010_12 |