HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-[2-(4-Benzo[b]thiophen-2-yl-5-bromo-pyrimidin-2-ylamino)-ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(2-Aminoethyl)-1,3-diaza-spiro[4.5]decane-2,4-dione | HCID 57428806 | — |
| Reactant | 4-(Benzo[b]thiophen-2-yl)-5-bromo-2-chloropyrimidine | HCID 57428821 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[2-(4-Benzo[b]thiophen-2-yl-5-bromo-pyrimidin-2-ylamino)-ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione | HCID 60204247 | — |
Reaction Conditions
| Temperature | 170 °C |
|---|
Reaction Steps
A mixture of 4-benzo[b]thiophen-2-yl-5-bromo-2-chloro-pyrimidine (318 mg, 1.0 mmol) and 1-(2-aminoethyl)-1,3-diaza-spiro[4.5]decane-2,4-dione (214 mg, 1.01 equiv.) in isopropyl alcohol (4 mL) was treated with diisopropylethylamine (192 μL, 1.1 equiv.) and heated at 170° C. for 17 min in a Personal Chemistry microwave reactor. Upon cooling, the product was obtained by filtration and washing with isopropyl alcohol, recrystallizing from hot isopropyl alcohol. MS (M+H)+ 500/502.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d81539a4ab084b1580c3662924945db3 |
| Source note | uspto-grants-2010_12 |