HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(2-Phenylsulfanyl-thiazol-5-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium benzenethiolate | HCID 4110039 | — |
| Reactant | 1-(2-Chlorothiazol-5-yl)ethanone | HCID 51777311 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2-Phenylsulfanyl-thiazol-5-yl)-ethanone | HCID 57428824 | — |
Reaction Steps
1-(2-Chloro-thiazol-5-yl)-ethanone (221 mg, 1.37 mmol) and sodium benzenethiolate (226 mg, 1.71 mmol) were added to acetone (20 mL) and stirred for 3 h. The suspension was poured into water (100 mL) containing 2 M aqueous NaOH (10 mL) and extracted with DCM (3×50 mL). The combined organic extracts were dried (Na2SO4) and concentrated to give the product. Yield=314 mg, 97%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-fe6c6fe87c274b7cbb4dda60391ed427 |
| Source note | uspto-grants-2010_12 |