反应详情

An opaque solution of 4-pivalamidopyridin-3-yl diethylcarbamodithioate (21.9 g, 67 mmol) in methanol (220 mL) and 1 N sodium hydroxide (220 mL) was stirred at r.t. for 20 h. Tlc showed consumption of starting material. The clear yellow solution was diluted with water (500 mL). After letting the turbid solution stand for 5 min, crystals precipitated out. The solid was filtered off, washed with water (2×50 mL) and diethyl ether (3×50 mL), and air dried to afford 4-aminopyridin-3-yl diethylcarbamodithioate (10.05 g, 62%) as colorless plate like crystals. 1H NMR: δ (CDCl3, 400 MHz) 1.30 (t, J=7 Hz, 3 H), 1.44 (t, J=7 Hz, 3 H), 3.90 (q, J=7 Hz, 2 H), 4.03 (q, J=7 Hz, 2 H), 4.68 (br. s., 2 H), 6.65 (d, J=5.5 Hz, 1 H), 8.25-8.30 (m, 2 H).

1. customconsumption of starting material
2. additionThe clear yellow solution was diluted with water (500 mL)
3. customfor 5 min
4. customcrystals precipitated out
5. filtrationThe solid was filtered off
6. washwashed with water (2×50 mL) and diethyl ether (3×50 mL), and air
7. customdried