Propan-2-one--water (1/1) → HCID 60204421, compound

HRID 2267330Notes

Reaction equation

HRID 2267330 reaction equation
CS[C:3]1[N:8]=[C:7]([C:9]2[S:13][C:12]([C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[O:15])=[CH:11][CH:10]=2)[CH:6]=[CH:5][N:4]=1.O[O:23][S:24]([O-:26])=O.[K+].[CH3:28]C(C)=O.O>>[CH3:28][S:24]([C:3]1[N:8]=[C:7]([C:9]2[S:13][C:12]([C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[O:15])=[CH:11][CH:10]=2)[CH:6]=[CH:5][N:4]=1)(=[O:26])=[O:23]

Participants

4

Reactant 3

HCID 18366337Propan-2-one--water (1/1)HCID 23707502Potassium hydroxy sulfiteHCID 60204420HCID 60204420, compound

Product 1

HCID 60204421HCID 60204421, compoundYield 83%

Procedure

A mixture of (5-(2-(methylthio)pyrimidin-4-yl)thiophen-2-yl)(morpholino)methanone (200 mg) and oxone (2 g) in 60 mL of acetone-water (1:1) was stirred at rt for 24 h. The mixture was concentrated in vacuo to remove the acetone. The white precipitate was filtered, washed with water and dried to give the title compound (183 mg, 83%). MS (M+H)+ 354.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customto remove the acetone
  3. filtrationThe white precipitate was filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-01f67f810cc84a94b6be3bac3e1d1488
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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