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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267361Generated: October 30, 2026

2-Thiocresol → 5,5-Dimethyl-1-(2-{4-[5-(o-tolylthio)thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidine-2,4-dione

https://huagongshe.com/reaction/2267361

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ThiocresolHCID 8712—
Reactant1-{2-[4-(5-Iodothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dioneHCID 60204465—
Product5,5-Dimethyl-1-(2-{4-[5-(o-tolylthio)thiophen-2-yl]pyrimidin-2-ylamino}ethyl)imidazolidine-2,4-dioneHCID 60204480—

Reaction Steps

The title compound was prepared from 1-{2-[4-(5-iodothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethyl-imidazolidine-2,4-dione and 2-methylthiophenol in a manner analogous to Example 259. MS (M+H)+ 454.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858785B2
Source datasetuspto-grants-2010_12
ORD IDord-e51105c55bb14bcfbf186d55d44586a4
Source noteuspto-grants-2010_12