HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-hydroxyphenyl)boronic Acid → 1-{2-[4-(5-Chlorothiophen-2-yl)-5-(3-hydroxyphenyl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-hydroxyphenyl)boronic Acid | HCID 2734359 | — |
| Reactant | 1-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204470 | — |
| Product | 1-{2-[4-(5-Chlorothiophen-2-yl)-5-(3-hydroxyphenyl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204490 | — |
Reaction Steps
The title compound was prepared from 1-{2-[5-bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione and 3-hydroxyphenylboronic acid in a manner analogous to Example 269. MS (M+H)+ 458.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-f3c07b2945a14ab59c87d2562e1d6560 |
| Source note | uspto-grants-2010_12 |