HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-(Hydroxymethyl)phenyl]boronic acid → 1-(2-{4-(5-Chlorothiophen-2-yl)-5-[3-(hydroxymethyl)phenyl]pyrimidin-2-ylamino}ethyl)-5,5-dimethylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-(Hydroxymethyl)phenyl]boronic acid | HCID 2734662 | — |
| Reactant | 1-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione | HCID 60204470 | — |
| Product | 1-(2-{4-(5-Chlorothiophen-2-yl)-5-[3-(hydroxymethyl)phenyl]pyrimidin-2-ylamino}ethyl)-5,5-dimethylimidazolidine-2,4-dione | HCID 60204491 | — |
Reaction Steps
The title compound was prepared from 1-{2-[5-bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione and 3-(hydroxymethyl)phenylboronic acid in a manner analogous to Example 269. MS (M+H)+ 472.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-97d3de4188da48bd915d1efd3099e14a |
| Source note | uspto-grants-2010_12 |