3-Aminophenylboronic acid → HCID 60204493, compound

HRID 2267369Notes

Reaction equation

HRID 2267369 reaction equation
Br[C:2]1[C:3]([C:20]2[S:21][C:22]([Cl:25])=[CH:23][CH:24]=2)=[N:4][C:5]([NH:8][CH2:9][CH2:10][N:11]2[C:15]([CH3:17])([CH3:16])[C:14](=[O:18])[NH:13][C:12]2=[O:19])=[N:6][CH:7]=1.[NH2:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[CH:31][CH:32]=1>>[NH2:26][C:27]1[CH:32]=[C:31]([C:2]2[C:3]([C:20]3[S:21][C:22]([Cl:25])=[CH:23][CH:24]=3)=[N:4][C:5]([NH:8][CH2:9][CH2:10][N:11]3[C:15]([CH3:17])([CH3:16])[C:14](=[O:18])[NH:13][C:12]3=[O:19])=[N:6][CH:7]=2)[CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 922693-Aminophenylboronic acidHCID 602044701-{2-[5-Bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione

Product 1

HCID 60204493HCID 60204493, compound

Procedure

The title compound was prepared from 1-{2-[5-bromo-4-(5-chlorothiophen-2-yl)pyrimidin-2-ylamino]ethyl}-5,5-dimethylimidazolidine-2,4-dione and 3-aminophenylboronic acid, hemihydrosulfate in a manner analogous to Example 269. MS (M+H)+ 457.

Sources & evidence

ORD record
ord-daf92f74a1484d9ca0f539e65ec85811
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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