Methanol → 1-{2-[4-(5-Benzyl-thiophen-2-yl)-pyrimidin-2-ylamino]-ethyl}-5,5-dimethyl-imidazolidine-2,4-dione

Participants

Reaction Conditions

Reaction Steps

A 10% (w/v) solution of 1-(2-aminoethyl)-5,5-dimethylimidazolidine-2,4-dione in MeOH (0.93 mL, 0.54 mmol) was added to a 5 mL microwave vessel. The MeOH was evaporated with a stream of N2 to leave an oily solid which was dissolved in 94 μl (0.54 mmol) of N,N-diisopropylethylamine and 2 mL of iPrOH, to which was added 0.15 g (0.54 mmol) of 4-(5-benzylthiophen-2-yl)-2-chloropyrimidine. The reaction solution was heated in a microwave to 170° C. for 20 min and then allowed to stand at rt for 2 h to give a precipitate which was collected by filtration and purified by C-8 prep HPLC to give the title compound. MS (M+H)+ 422.

Provenance & Evidence