Thiophene, 2-(phenylmethyl)- → 4-(5-Benzylthiophen-2-yl)-5-bromo-2-chloro-pyrimidine

HRID 2267376Notes

Reaction equation

HRID 2267376 reaction equation
[CH2:1]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:15]=[N:16][C:17]([Cl:20])=[N:18][CH:19]=1>>[CH2:1]([C:8]1[S:9][C:10]([C:15]2[C:14]([Br:13])=[CH:19][N:18]=[C:17]([Cl:20])[N:16]=2)=[CH:11][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 139391Thiophene, 2-(phenylmethyl)-HCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 574288384-(5-Benzylthiophen-2-yl)-5-bromo-2-chloro-pyrimidine

Procedure

The title compound was prepared from 2-benzylthiophene and 5-bromo-2-chloropyrimidine in a manner analogous to Example 255, Step 1. MS (M+H)+ 365.

Sources & evidence

ORD record
ord-6f4f24a77cda446792f3dfc2cb7fd83d
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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