化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromothiazole → Thiazole, 2-(phenylthio)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromothiazole | HCID 76430 | — |
| 反応物 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 反応物 | Sodium benzenethiolate | HCID 4110039 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Thiazole, 2-(phenylthio)- | HCID 606073 | — |
反応手順
A solution of sodium thiophenolate (0.61 g, 4.62 mmol) and 2-bromothiazole (0.38 mL, 4.2 mmol) in 20 mL of toluene was treated with 0.19 g (0.21 mmol) of Pd2 dba3 and 0.12 g (0.21 mmol) of Xantphos and heated at reflux for 10 min. The crude solution was concentrated onto 5 g of silica gel and then purified by flash chromatography to give the title compound. MS (M+H)+ 194.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07858785B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-b293ff19c34b47eab179a2aa20417395 |
| 出典メモ | uspto-grants-2010_12 |