2-Chloro-5-fluoropyrimidine → HCID 11705229, compound

HRID 2267416Notes

Reaction equation

HRID 2267416 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2[S:11][CH:10]=[N:9][CH:8]=2)=[CH:4][CH:3]=1.Cl[C:15]1[N:20]=[CH:19][C:18]([F:21])=[CH:17][N:16]=1.[NH2:22][CH2:23][CH2:24][N:25]1[C:29]([CH3:31])([CH3:30])[C:28](=[O:32])[NH:27][C:26]1=[O:33]>>[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2[S:11][C:10]([C:17]3[C:18]([F:21])=[CH:19][N:20]=[C:15]([NH:22][CH2:23][CH2:24][N:25]4[C:29]([CH3:30])([CH3:31])[C:28](=[O:32])[NH:27][C:26]4=[O:33])[N:16]=3)=[N:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 5834662-Chloro-5-fluoropyrimidineHCID 19963296HCID 19963296, compoundHCID 574288041-(2-Aminoethyl)-5,5-dimethylimidazolidine-2,4-dione

Product 1

HCID 11705229HCID 11705229, compound

Procedure

5-(4-Fluorobenzyl)thiazole was condensed with 2-chloro-5-fluoropyrimidine and subsequently aminated with 1-(2-aminoethyl)-5,5-dimethylimidazolidine-2,4-dione using procedures analogous to those in Example 24. MS (M+H)+ 459.

Sources & evidence

ORD record
ord-583fd5586a0947ddab4054a86cec5db8
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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