Water → 5-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine

HRID 2267427Notes

Reaction equation

HRID 2267427 reaction equation
[CH3:1][C:2]1[C:3]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1.[OH2:15].[OH:16]OS([O-])=O.[K+]>CC(C)=O>[CH3:1][C:2]1[C:3]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[N:4][C:5]([S:8]([CH3:9])(=[O:16])=[O:15])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 574288625-Methyl-2-(methylthio)-4-(thiophen-2-yl)pyrimidine

Product 1

HCID 574288635-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-Methyl-2-(methylthio)-4-(thiophen-2-yl)pyrimidine (0.15 g, 0.67 mmol) was dissolved in acetone (10 mL) and then water (10 mL) was added. Oxone (1.2 g, 2.02 mmol) was added in small portions to the reaction mixture, which was allowed to stir overnight at ambient temperature. The white precipitate that formed during the course of the reaction was collected by suction filtration and washed several times with water and then dried in a vacuum oven at 60° C. Yield=0.12 g. MS (M+H)+ 255.

Workup

  1. customThe white precipitate that formed during the course of the reaction
  2. filtrationwas collected by suction filtration
  3. washwashed several times with water
  4. customdried in a vacuum oven at 60° C

Sources & evidence

ORD record
ord-b406d2dc06ed4b02a8ab30735d51ff87
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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