HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 1-(2-(5-Methyl-4-(thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | N-(2-Aminoethyl)ethyleneurea | HCID 80480 | — |
| Reactant | 5-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine | HCID 57428863 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-(5-Methyl-4-(thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one | HCID 60204553 | — |
Reaction Conditions
| Temperature | 200 °C |
|---|
Reaction Steps
5-Methyl-2-(methylsulfonyl)-4-(thiophen-2-yl)pyrimidine (0.1 g, 0.39 mmol) and 1-(2-aminoethyl)imidazolidin-2-one (0.06 g, 047 mmol) were added to a microwave tube along with toluene (1 mL). The tube was capped and heated to 200° C. for 10 min in a Personal Chemistry microwave. The mixture was diluted with dichloromethane and purified by flash chromatography using a gradient of 2 to 10% methanol in dichloromethane to obtain an off-white solid. Yield=0.03 g. MS (M+H)+ 304.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858785B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e827f830b1ae4db687e3b81c24489970 |
| Source note | uspto-grants-2010_12 |