HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-(3-thienyl)-1H-indol-3-yl]-1-piperidinecarboxylate | HCID 59600655 | — |
| Reactant | 3-(4-piperidinyl)-5-(2-thienyl)-1H-indole-7-carboxamide | HCID 59600661 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide | HCID 59600664 | — |
Reaction Steps
The title compound was prepared according to the general procedure for intermediate 17. Thus, 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-(3-thienyl)-1H-indol-3-yl]-1-piperidinecarboxylate (460 mg, 1.08 mmol) and HCl (4.0M in dioxane, 10 mL) in MeOH (5 mL) was reacted to form the desired product without further purification (260 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858796B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c034074e77884819bfd900f4079b66d1 |
| Source note | uspto-grants-2010_12 |