HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(2-thienyl)-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloropropanesulphonyl chloride | HCID 15410 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Reactant | 3-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide | HCID 59600664 | — |
| Product | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(2-thienyl)-1H-indole-7-carboxamide | HCID 59003323 | 64% |
Reaction Steps
The title compound was prepared according to the general procedure for intermediate 11. 3-(4-piperidinyl)-5-(3-thienyl)-1H-indole-7-carboxamide (275 mg, 0.84 mmol) was reacted with triethyl amine (0.35 mL, 2.52 mmol) and 3-chloropropylsulfonyl chloride (0.4 mL, 1.68 mmol) to give the title compound (250 mg, 64%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858796B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-92f9126e3c254a718472f58fb45c671e |
| Source note | uspto-grants-2010_12 |