HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-bromo-3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloropropanesulphonyl chloride | HCID 15410 | — |
| Reactant | 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide | HCID 11324722 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Product | 5-bromo-3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide | HCID 59003310 | 52% |
Reaction Steps
The title compound was prepared according to the general procedure for intermediate 11. 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide (875 mg, 2.72 mmol) was reacted with triethyl amine (2.27 mL, 16.32 mmol) and 3-chloropropylsulfonyl chloride (0.64 mL, 5.44 mmol) to give the title compound (656 mg, 52%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858796B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-f24de586e08b4729a3fcc1a8dedc9369 |
| Source note | uspto-grants-2010_12 |