Potassium Carbonate → HCID 59003341, compound

Participants

Reaction Steps

The title compound was prepared according to the general procedure for intermediate 16. Thus, 5-bromo-3-(1-{[3-(4-morpholinyl)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide (400 mg, 0.78 mmol) in dioxane (3 mL) and water (1 mL), [5-(hydroxymethyl)-2-thienyl]boronic acid (493 mg, 3.12 mmol), Pd(PPh3)4 (90 mg, 10%) and potassium carbonate (861 mg, 6.24 mmol) were reacted to form the desired product which was purified by flash column chromatography (ethyl acetate/hexane, 1/1) to yield the desired product (83 mg, 20%).

Provenance & Evidence