反应详情

The mixture of 5-bromo-3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-1H-indole-7-carboxamide (23 mg, 0.050 mmol), 0.1 M NaOMe (1 ml) in methanol (1 mL) was refluxed overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (18.0 mg, 78%).

1. temperaturewas refluxed overnight
2. concentrationThe reaction mixture was concentrated
3. custompurified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%)