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HRID226751

反应详情

EQUATION

反应方程式

HRID 226751 的结构方程式

REACTANTS

反应物

2
结构：Nc1cccc(O)c1
HCID11568

3-Aminophenol

C6H7NO

结构：COc1cc(Nc2nc(Cl)ncc2F)cc(OC)c1
HCID22060694

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(Nc2nc(Nc3cccc(O)c3)ncc2F)cc(OC)c1
HCID22060588

未命名化合物

PROCEDURE

实验过程

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-N4-(3,5-dimethoxyphenyl)-5-fluoro-4-pyrimidineamine with 3-hydroxyaniline gave N4-(3,5-dimethoxyphenyl)-N2-(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 18.98 min.; purity: 90%; MS (m/e): 357 (MH+).

WORKUP

后处理

  1. customIn like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine