Sodium Iodide → HCID 11555269, compound

Participants

Reaction Steps

Following the general procedure for aminosulfonamide formation outlined in example 2, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (62 mg, 0.13 mmol) and piperidine (55.25 mg, 0.65 mmol) were allowed to react in the presence of K2CO3 (72 mg, 0.56 mmol) and NaI (Cat. 2.0 mg). The resulting residue purified by reverse phase HPLC eluting with 10% B to 80% B, where A=H2O (0.1% trifluoroacetic acid) and B=CH3CN (0.1% trifluoroacetic acid) to give the title compound (31.5 mg, 46%).

Provenance & Evidence