Sodium Iodide → 3-[1-({2-[(4-hydroxycyclohexyl)amino]ethyl}sulfonyl)-4-piperidinyl]-5-(3-thienyl)-1H-indole-7-carboxamide

Participants

Reaction Steps

Following the general procedure for aminosulfonamide formation outlined in example 2, 3-{1-[(2-chloroethyl)sulfonyl]-4-piperidinyl}-5-(3-thienyl)-1H-indole-7-carboxamide (0.09 mmol) and 4-aminocyclohexanol (33.4 mg, 0.45 mmol) were allowed to react in the presence of K2CO3 (44 mg, 0.45 mmol) and NaI (Cat. 5 mg). The resulting residue was purified by reverse phase HPLC eluting with 10% B to 80% B, where A=H2O (0.1% trifluoroacetic acid) and B=CH3CN (0.1% trifluoroacetic acid) to give the title compound (3.6 mg, 7.7%).

Provenance & Evidence