Sodium Iodide → HCID 59003343, compound

Participants

Reaction Steps

Following the general procedure for aminosulfonamide formation outlined in example 2, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (100 mg, 0.313 mmol) and (2R,5R)-2,5-dimethylpyrrolidine (449 mg, 1.56 mmol) were allowed to react in the presence of K2CO3 (886 mg, 0.63 mmol) and NaI (251 mg, 1.56 mmol). The resulting residue was purified by reverse phase HPLC eluting with 10% B to 80% B, where A=H2O (0.1% trifluoroacetic acid) and B=CH3CN (0.1% trifluoroacetic acid) to give the title compound (60 mg, 37%).

Provenance & Evidence