Triethylamine → 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(4-fluorophenyl)-1H-indole-7-carboxamide

Participants

Reaction Steps

3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(4-fluorophenyl)-1H-indole-7-carboxamide was prepared according to the procedure for intermediate 11. 5-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide (20 mg, 0.059 mmol) was reacted with triethyl amine (0.03 mL, 0.236 mmol) and 3-chloropropylsulfonyl chloride (0.03 mL, 0.118 mmol) to give 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(4-fluorophenyl)-1H-indole-7-carboxamide, which was used in the next step without further purification.

Provenance & Evidence