Sodium Iodide → HCID 11526363, compound

Participants

Reaction Steps

Following the general procedure for aminosulfonamide formation outlined in example 2, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(4-fluorophenyl)-1H-indole-7-carboxamide (0.059 mmol) and pyrrolidine (0.025 mL, 0.295 mmol) were allowed to react in the presence of K2CO3 (37 mg, 0.118 mmol) and NaI (Cat. 2 mg). The resulting residue was purified by reverse phase HPLC eluting with 10% B to 80% B, where A=H2O (0.1% trifluoroacetic acid) and B=CH3CN (0.1% trifluoroacetic acid) to give the title compound (6.9 mg, 23%).

Provenance & Evidence