Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Cresol | HCID 2879 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 11548273 | HCID 11548273 | 14% |
Reaction Steps
To a solution of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (40 mg, 0.087 mmol) in DMSO (1.0 mL), were added 4-methylphenol (108 mg, 0.87 mmol), K2CO3 (35.0 mg, 0.35 mmol) and sodium iodide (0.5 mg). The reaction solution was heated to 80° C. overnight. After which time the reaction mixture was filtered and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (6.3 mg, 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07858796B2 |
|---|
| Source dataset | uspto-grants-2010_12 |
|---|
| ORD ID | ord-53865628163e4a6fb3a7f382f933e464 |
|---|
| Source note | uspto-grants-2010_12 |
|---|
