HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267569Generated: November 2, 2026
Sodium ethoxide → 3-(1-{[3-(ethyloxy)propyl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide
https://huagongshe.com/reaction/2267569
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1-{[3-(ethyloxy)propyl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide | HCID 59003346 | 64% |
Reaction Steps
The mixture of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (23 mg, 0.050 mmol), NaOEt (10 mg) in ethanol (1 mL) was refluxed at 80° C. overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (15.0 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07858796B2 |
|---|
| Source dataset | uspto-grants-2010_12 |
|---|
| ORD ID | ord-4622148c564e430cb99d0e8bb828af42 |
|---|
| Source note | uspto-grants-2010_12 |
|---|
