Triethylamine → 3-{1-[(1,2-dimethyl-1H-imidazol-5-yl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide

Participants

Reaction Steps

Following the general procedure in example 267, 5-(phenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide (72 mg, 0.22 mmol), 1,2-dimethyl-1H-imidazole-5-sulfonyl chloride (64.2 mg, 0.33 mmol) and triethylamine (0.13 mL, 0.66 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (48.3 mg, 45%).

Provenance & Evidence