Sodium Iodide → HCID 59003337, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (23.0 mg, 0.05 mmol) in DMSO (1.0 mL), were added 3-ethylphenol (122.0 mg, 0.5 mmol), K2CO3 (35.0 mg, 0.25 mmol) and sodium iodide (1.0 mg). The reaction solution was heated to 80° C. overnight. After which time the reaction mixture was filtered and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (5 mg, 18%).

Provenance & Evidence