Acrylate → HCID 68607668, compound

HRID 2267612Notes

Reaction equation

HRID 2267612 reaction equation
[CH2:1]([O:8][C:9]([NH:11]/[C:12](=[CH:17]\[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1)/[C:13]([O:15][CH3:16])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C=C.[SH:33][CH2:34][CH2:35][NH:36][C:37](=[O:43])[O:38][C:39]([CH3:42])([CH3:41])[CH3:40]>>[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:13]([O:15][CH3:16])=[O:14])[CH:17]([C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1)[S:33][CH2:34][CH2:35][NH:36][C:37]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:43])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 25188AcrylateHCID 3017761N-(tert-butoxycarbonyl)-2-aminoethanethiolHCID 15184929HCID 15184929, compound

Product 1

HCID 68607668HCID 68607668, compound

Procedure

Using a procedure similar to that described in Example 10 part b, substituting methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(1-naphthyl)acrylate (5a) (2.8 g, 7.75 mmol) as the acrylate component and tert-butyl (2-mercaptoethyl)carbamate (5.3 g, 29.9 mmol) as the thio component (stirred 5 days), the title compound (25b) was obtained (3.3 g, 79%) as a semi-solid.

Sources & evidence

ORD record
ord-fc3a434d4a004de9a0f953c66faa91af
Source dataset
uspto-grants-2010_12
Patent number
US07858776B2

Reaction notes

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