Hydrochloric Acid → HCID 68605811, compound

Participants

Reaction Steps

To a stirred solution of methyl N-[(benzyloxy)carbonyl]-S-{2-[(tert-butoxycarbonyl)amino]ethyl}-3-(1-naphthyl)cysteinate (25b) (3.3 g, 6.13 mmol) in ethyl acetate (80 mL) at −30° C., was bubbled over HCl gas for 10 min, stirred at −30° for 15 min and then allowed to RT for 3 h. Evaporation to near dryness and precipitation from ether afforded pure title compound (25) (2.6 g, 89%) as a white solid. MS APCI, m/z=439 (M+1), 2.34 min.

Provenance & Evidence