3-Thiophenecarboxaldehyde → HCID 86604645, compound

HRID 2267652Notes

Reaction equation

HRID 2267652 reaction equation
[CH2:1]([O:8][C:9]([NH:11]/[C:12](=[CH:17]\[C:18]1SC=[CH:21][CH:22]=1)/[C:13]([O:15][CH3:16])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:23]1C=CC(C=O)=[CH:24]1>>[CH2:1]([O:8][C:9]([NH:11]/[C:12](=[CH:17]\[C:18]1[CH:22]=[CH:21][S:23][CH:24]=1)/[C:13]([O:15][CH3:16])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 681353-ThiophenecarboxaldehydeHCID 15184928HCID 15184928, compound

Product 1

HCID 86604645HCID 86604645, compound

Procedure

A method similar to that used for the preparation of (99a) was used except that 3-thiophenecarboxaldehyde (762 mg) was used as the aldehyde component to afforded the desired product (549 mg). 1H NMR (300 MHz, CDCl3) δ 3.795 (s, 3H), 5.19 (s, 2H), 5.99 (br., 1H), 7.07 (m, 1H), 7.34 (m, 7H), 7.49 (d, 111, J=5 Hz), 7.77 (s, 1H). LC/MS: 2.32 min.

Sources & evidence

ORD record
ord-fc4730376ef3444b8440837ab9f50246
Source dataset
uspto-grants-2010_12
Patent number
US07858776B2

Reaction notes

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