HCID 14648554, compound → HCID 86619277, compound

HRID 2267654Notes

Reaction equation

HRID 2267654 reaction equation
[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[S:5][C@@H:4](C2SC=CC=2)[C@H:3]1[NH:18][C:19](=[O:28])[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(OC(N/C(=C\[C:46]1[CH:50]=[CH:49][O:48][CH:47]=1)/C(OC)=O)=O)C1C=CC=CC=1>>[CH2:21]([O:20][C:19](=[O:28])[NH:18][C@H:3]1[C:2](=[O:1])[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[S:5][C@@H:4]1[C:46]1[CH:50]=[CH:49][O:48][CH:47]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 14648554HCID 14648554, compoundHCID 86619278HCID 86619278, compound

Product 1

HCID 86619277HCID 86619277, compound

Procedure

A method similar to that used for the preparation of (99b) was used except that methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(3-furyl)acrylate (102a) (530 mg) was used as starting material to afford the title compound as a white solid (235 mg). 1H NMR (300 MHz, d6-DMSO) δ 4.66 (t, 1H, J=4 Hz), 4.97 (s, 2H), 5.20 (d, 1H, J=6 Hz), 6.38 (d, 2H, J=7 Hz), 6.5 (s, 1H), 7.07-7.75 (m, 1H), 10.44 (s, 1H). LC/MS: 2.32 min.

Sources & evidence

ORD record
ord-fd58fdbe6f264dbfab3a913b7daadea2
Source dataset
uspto-grants-2010_12
Patent number
US07858776B2

Reaction notes

Loading…