HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromothiophene-2-carbaldehyde → HCID 131726681, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromothiophene-2-carbaldehyde | HCID 78428 | — |
| Reactant | HCID 15184928 | HCID 15184928 | — |
| Reactant | (2s)-2-[(3,5-Difluorophenyl)acetyl]amino-n-[(6r,7r)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-2-phenylacetamide | HCID 68604124 | — |
| Product | HCID 131726681 | HCID 131726681 | — |
Reaction Steps
A method similar to that used for the preparation of (99a) was used except that the reaction product was passed through a Dowex ion exchange resin 50×2-200 and 5-bromo-2-thiphenecarboxaldehyde (955 mg) was used as the aldehyde component to afforded the desired product (1.80 g). 1H NMR (300 MHz, CDCl3) δ 3.79 (s, 3H), 5.20 (s, 2H), 5.93 (br., 1H), 6.95 (m, 1H), 7.36 (m, 5H), 7.70 (s, 1H). LC/MS: 2.36 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858776B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-bb16a30a183843a6ac8efb56e063e6a9 |
| Source note | uspto-grants-2010_12 |