HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromothiophene-2-carbaldehyde → HCID 86604644, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| Reactant | HCID 15184928 | HCID 15184928 | — |
| Reactant | (2s)-2-[(3,5-Difluorophenyl)acetyl]amino-n-[(6r,7r)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-2-phenylacetamide | HCID 68604124 | — |
| Product | HCID 86604644 | HCID 86604644 | — |
Reaction Steps
A method similar to that used for the preparation of (99a) was used except that the reaction product was passed through a Dowex ion exchange resin 50×2-200 and 4-bromo-2-thiphenecarboxaldehyde (955 mg) was used as the aldehyde component to afford the desired product (1.52 g). 1H NMR (300 MHz, CDCl3) δ 3.79 (s, 3H), 5.24 (s, 2H), 5.99 (br., 1H), 7.20-7.37 (m, 7H), 7.67 (s, 1H). LC/MS: 2.37 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858776B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b5bb1f7081ec461bb9f648b78846ae89 |
| Source note | uspto-grants-2010_12 |