2-(4-Fluorophenyl)acetic acid → HCID 10095834, compound

Participants

Reaction Steps

A method similar to the one described for (113) was used except that 4-fluorophenylacetic acid (77 mg) was used instead of phenylacetic acid to afford the title compound as a 1:1 mixture with the 2S,3R diastereomer (134 mg), white solid, m.p. 130-140° C. 1H NMR (300 MHz, CDCl3) δ 0.97 (d, 1.5H, J=5 Hz), 1.07 (d, 1.5H, J=5 Hz), 3.43 (two peaks, 2H), 4.52 (m, 0.5H), 4.57 (m, 0.5 H), 4.93 (t, 1H, J=6 Hz), 5.11 (t, 1H, J=6 Hz), 5.78 (dd, 1H, J=7 Hz, J=10 Hz), 6.05 (d, 0.5H, J=8 Hz), 6.21 (d, 0.5 Hz, J=8 Hz), 6.33 (d, 0.5h, J=6 Hz), 6.66 (d, 0.5H, J=7 Hz), 6.88-7.60 (m, 13H), 7.96 (s, 1H). MS APCI, m/z=484 (M+Na). LC/MS: 2.10 min.

Provenance & Evidence