HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-(N-Boc-amino)piperidine | HCID 4438618 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(N-Boc-amino)piperidine | HCID 723833 | 76% |
Reaction Steps
A solution of the ester 2 from above (66 g, 227.27 mmol) in 1 l of ethanol is hydrogenated under normal pressure with 10 g of Pd/C (10%) for 16 hours at room temperature. The mixture is filtered over celite and evaporated under reduced pressure. Recrystallisation from ether gave 34.5 g (76%) of white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-74ad6607447944d3861c13fade3bef11 |
| Source note | uspto-grants-2010_12 |