Hydrochloric Acid → (R)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-piperidin-3-ol tri-hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	1,4-Dioxane	HCID 31275	—
Reactant	1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride	HCID 66841322	—
Reactant	{1-[2-((R)-3-Hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester	HCID 66842084	—
Product	(R)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-piperidin-3-ol tri-hydrochloride	HCID 66841528	—

It is prepared by BOC-cleavage of tert-butyl ester 13 (1.7 g, 5.19 mmol) with 4M-HCl in dioxane (10.4 ml, 41.52 mmol) as described for amine 7.