1-Benzyl-3,5-dimethylpiperidin-4-one → 1-Benzyl-3,5-dimethylpiperidin-4-ol

HRID 2267703Notes

Reaction equation

HRID 2267703 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]([CH3:14])[C:11](=[O:15])[CH:10]([CH3:16])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[CH2:1]([N:8]1[CH2:13][CH:12]([CH3:14])[CH:11]([OH:15])[CH:10]([CH3:16])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 222789201-Benzyl-3,5-dimethylpiperidin-4-one

Product 1

HCID 230036661-Benzyl-3,5-dimethylpiperidin-4-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodiumboronhydride (121 mg, 3.2 mmol) is added to a solution of 44 (1.4 g, 6.4 mmol) in 15 ml of methanol and the mixture is stirred at room temperature for 30 min. The mixture is evaporated, and the residue is dissolved in ethyl acetate and washed with water.

Workup

  1. customThe mixture is evaporated
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. washwashed with water

Sources & evidence

ORD record
ord-e0f2ec01678d4f64ae1202fca7b699cf
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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