反应详情

Ester 54 from above (1.7 g, 3.52 mmol) is treated with NaOMe (0.5M in methanol, 21 ml, 10.5 mmol) and heated under reflux for 24 hours. The solvent is then evaporated, the residue taken up in DCM and extracted with 1N—NaOH and brine. After drying and evaporation the crued is purified by chromatography on silicagel using DCM (saturated with ammonia) and MeOH (from 1% to 3%) to give a white powder.

1. temperatureheated
2. temperatureunder reflux for 24 hours
3. customThe solvent is then evaporated
4. extractionextracted with 1N—NaOH and brine
5. customAfter drying
6. customevaporation the
7. customcrued is purified by chromatography on silicagel
8. customto give a white powder